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Research TutorialsResearch Tutorials MetabonomicsMetabonomics Applications in Drug DevelopmentApplications in Drug Development Structure Elucidation of New BiomarkersStructure Elucidation of New Biomarkers Ranking StudyRanking Study
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Ph. D. Thesis
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    Biology and "-omics"
    Definition of Metabonomics
    Applications in Drug Development
      Possiblities and Examples
      Specific Biomarkers
      Patterns of Biomarkers
      Structure Elucidation of New Biomarkers
        Competitive Study
        Ranking Study
          Influences of Study Protocol
          Clustering of Compounds
          Statistical Identification of Correlated Signals
          HSQC 2D-NMR
          Validation of Structure Identity
          Biochemical Interpretation
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Structure Elucidation - Ranking Study

In a ranking study, which is also called drug candidate selection study, several drug candidates are ranked in many respects. In this study the toxicity of 5 drug candidates was investigated by metabonomics. Ranking studies are typically very small studies. In this case, the study protocol was limited to 4 animals per compound, one shared control group, one pre-dose sampling time point and one post-dose sampling time point. The study protocol was not adapted to specific requirements of metabonomic studies, as metabonomic analyses were an addendum to typical toxicology investigations performed anyway for this study.




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